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Le lots) and biofunctional parameters. The biofunctional parameters tested include an assessment of both binding and function within both the Fab and Fc portions of the mAb.Acknowledgments The authors thank Abhishek Mathur for scientific and technical contributions to the reported data and Jennifer Liu, Jill Crouse-Zeineddini, and Scott Kuhns for guidance on overall similarity assessment strategy.

E signature sequences in different proteins support the division of Archaebacteria into two distinct groups (Euryarchaeota and Crenarchaeota) and of gram-positive bacteria into at least two groups, corresponding to the low-G C and high-G C species, of which the high-G C group is specifically related to the diderm prokaryotes. The DeinococcusThermus group of species appears to be intermediate in th

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