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Introduced mutations into the conserved CxxxPxC sequence and the unique LxCxE motif within the C-terminus of JCV tAg. Using a coimmunoprecipitation approach, we confirmed our prediction that the P99A mutant tAg would exhibit a loss of PP2A binding activity. This proline is conserved in the tAgs of primate polyomaviruses as well as of mouse polyoma virus.JCV Small t Protein FunctionsFigure 7. JCV t

Introduced mutations into the conserved CxxxPxC sequence and the unique LxCxE motif within the C-terminus of JCV tAg. Using a coimmunoprecipitation approach, we confirmed our prediction that the P99A mutant tAg would exhibit a loss of PP2A binding activity. This proline is conserved in the tAgs of primate polyomaviruses as well as of mouse polyoma virus.JCV Small t Protein FunctionsFigure 7. JCV t

Ared the frail population to the non-frail population. Results: Two hundred and eighty four patients were admitted to Intensive Care in this time period. Of those, 102 were over the age of 65 years. Of the 102 patients, 68patients were deemed to be frail, and 34 were deemed to be non-frail using the CFS. Approximately 40 of the patients admitted to Intensive Care are over the age of 65. There wa

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