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Secrete streptokinase in order to accelerate the conversion of human plasminogen to plasmin (12). Lacking enzymatic activity itself, streptokinase evolves its function by forming a stoichiometric 1:1 complex with plasminogen or a trimolecular complex with plasminogen and fibrinogen. The activator complexes can bind at the bacterial surface via host factor receptors and convert other plasminogen mo
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For removal in patients with septic shock, without an obvious other source of infection as the absence of local signs and symptoms are notoriously insensitive in the neutropenic host. In a cohort study of neutropenic cancer patients admitted to the ICU for severe sepsis or septic shock, Legrand et al. found that routinely removing indwelling catheters early on in patients with no other detectable
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